Cardiac Conduction System Anomalies and Sudden Cardiac Death: Insights from Murine Models

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Cardiac Conduction System Anomalies and Sudden Cardiac Death: Insights from Murine Models

The cardiac conduction system (CCS) is composed of a group of myocardial tissues that control and coordinate the heart. Alterations in the CCS - especially in the His-Purkinje system, have been identified as a major cause of lethal arrhythmias. Unstable arrhythmias secondary to channelopathies significantly increase the risk of sudden cardiac death (SCD). SCD is a major contributor to mortality...

متن کامل

CAP2 in cardiac conduction, sudden cardiac death and eye development

Sudden cardiac death kills 180,000 to 450,000 Americans annually, predominantly males. A locus that confers a risk for sudden cardiac death, cardiac conduction disease, and a newly described developmental disorder (6p22 syndrome) is located at 6p22. One gene at 6p22 is CAP2, which encodes a cytoskeletal protein that regulates actin dynamics. To determine the role of CAP2 in vivo, we generated k...

متن کامل

Sudden Cardiac Death Epidemiology and Genetics of Sudden Cardiac Death

From the Section of Electrophysiology, Division of Cardiovascular Medicine, University of Pennsylvania, Philadelphia, PA (R.D.); Division of Preventive Medicine and Cardiovascular Medicine, Center for Arrhythmia Prevention, Brigham and Women’s Hospital, Boston, MA (C.M.A.). Correspondence to Christine M. Albert, MD, MPH, Division of Preventive Medicine and Cardiovascular Medicine, Center for Ar...

متن کامل

Sudden Cardiac Death Sudden Death From Genetic and Acquired Cardiomyopathies

From the Aphorisms of Hippocrates to the sports fields of the twenty-first century, by both the lay public and the medical community, the cardiomyopathies have been recognized as causes of sudden cardiac death (SCD). Prevention of SCD in the cardiomyopathies is a 2-fold challenge. First, and central to clinical practice, is the need for reliable prognostication in individuals with established d...

متن کامل

Sudden Cardiac Death Sudden Cardiac Death in the Athlete

Sudden cardiac death (SCD) in a young athlete commonly brings to the forefront the many gaps in knowledge regarding how to predict and prevent these rare tragic events.1–3 Although the number of athletic sudden deaths is relatively small, with 100 to 150 competitive deaths during sports in the United States annually, they represent an important and emotionally charged public health issue, perha...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Frontiers in Physiology

سال: 2012

ISSN: 1664-042X

DOI: 10.3389/fphys.2012.00211